a – The unweighted proportion of SARS-CoV-2 circulating in the United States that contain the designated substitution, based on >60,000 sequences collected through CDC’s national genomic surveillance during the two-week period ending August 28, 2021.
b – The unweighted regional proportion of SARS-CoV-2 circulating in each HHS region that contain the designated substitution, based on >60,000 sequences collected through CDC’s national genomic surveillance during the two-week period ending August 28, 2021.
c – The lineages listed are the most common lineages within CDC’s national genomic surveillance with these substitutions, but this list is not intended to be a complete list of the lineages that contain the spike protein substitutions.